The influence of genetic variation on gene expression
نویسندگان
چکیده
منابع مشابه
The influence of genetic variation on gene expression.
The view that changes to the control of gene expression rather than alterations to protein sequence are central to the evolution of organisms has become something of a truism in molecular biology. In reality, the direct evidence for this is limited, and only recently have we had the ability to look more globally at how genetic variation influences gene expression, focusing upon inter-individual...
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15 صفحه اولImpact of Natural Genetic Variation on Gene Expression Dynamics
DNA sequence variation causes changes in gene expression, which in turn has profound effects on cellular states. These variations affect tissue development and may ultimately lead to pathological phenotypes. A genetic locus containing a sequence variation that affects gene expression is called an "expression quantitative trait locus" (eQTL). Whereas the impact of cellular context on expression ...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2007
ISSN: 1088-9051
DOI: 10.1101/gr.6981507